protein

HMOX2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HMOX2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Heme oxygenase 2 (HMOX2, HO-2) is a constitutively expressed enzyme that catalyzes the degradation of heme into biliverdin, carbon monoxide, and free iron.

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🔬 Protein Info

Gene Symbol	HMOX2PROTEIN
Chromosome	16q13.3
Protein Type	Enzyme
Function	is a constitutively expressed enzyme that catalyzes the degradation of heme into biliverdin, carbon monoxide, and free iron.
GeneCards	HMOX2PROTEIN
Human Protein Atlas	HMOX2PROTEIN
N-terminal membrane anchor	Anchors to endoplasmic reticulum
Heme-binding pocket	Contains the catalytic site
Histidine-rich region	Potential metal binding site
C-terminal domain	Contains heme regulatory motifs (HRMs)
Biliverdin	Converted to bilirubin, an antioxidant
Carbon monoxide (CO)	Signaling molecule
Free iron	Recycled via ferritin storage
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Heme Oxygenase 2

protein · 951 words

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Pathway Diagram

graph TD
    HMOX2PROTEIN["HMOX2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    HMOX2PROTEIN -->|"implicated_in"| neurodegeneration
    style HMOX2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HMOX2PROTEIN in their description or question text

No additional research found