Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HNRNPF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HNRNPF |
| Chromosome | 10q11.22 |
| Function | is an RNA-binding protein encoding gene located on chromosome 10q11. |
| Subcellular Localization | and protein interactions. [@geuens2016] |
| Molecular Weight | 46 kDa |
| Amino Acids | 415 aa |
| Exons | 11 |
| GeneCards | HNRNPF |
| Human Protein Atlas | HNRNPF |
| RRM1 (N-terminal) | Primary RNA-binding domain with high affinity for G-rich sequences |
| RRM2 (Central) | Contributes to RNA binding specificity |
| RRM3 (C-terminal) | Facilitates protein-protein interactions |
| Isoform 1 | Full-length protein (415 aa) - predominant form |
| Isoform 2 | Alternative exon inclusion (387 aa) |
| Isoform 3 | Truncated form with alternative C-terminus |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HNRNPF["HNRNPF"]
neurodegeneration["neurodegeneration"]
HNRNPF -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HNRNPF in their description or question text
No additional research found