Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HNRNPQ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HNRNPQ |
| Full Name | Heterogeneous Nuclear Ribonucleoprotein Q |
| Chromosome | 6p21.1 |
| Function | HNRNPQ (Heterogeneous Nuclear Ribonucleoprotein Q), also known as SYNCRIP or NSAP1, is an RNA-binding protein involved in multiple aspects of RNA metabolism. |
| Molecular Weight | 62 kDa |
| Amino Acids | 527 aa |
| Pathways | cofilin translation |
| UniProt ID | [O60506](https://www.uniprot.org/uniprot/O60506) |
| Ensembl ID | ENSG00000121316 |
| OMIM | 607210 |
| GeneCards | HNRNPQ |
| Human Protein Atlas | HNRNPQ |
| Brain | Highest expression in neurons |
| Testis | Spermatogenesis |
| Heart | Cardiac muscle |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HNRNPQ["HNRNPQ protein"]
mRNA_binding["mRNA binding and splicing"]
cofilin_translation["Cofilin translation regulation"]
cofilin["Cofilin protein"]
actin_dynamics["Actin cytoskeleton dynamics"]
spine_morphology["Dendritic spine morphology"]
synaptic_plasticity["Synaptic plasticity"]
RNA_granules["RNA transport granules"]
stress_granules["Stress granule formation"]
protein_aggregation["Protein aggregation"]
neuronal_dysfunction["Neuronal dysfunction"]
neurodegeneration["Neurodegeneration"]
ALS["Amyotrophic lateral sclerosis"]
FTD["Frontotemporal dementia"]
RNA_metabolism["RNA metabolism dysregulation"]
HNRNPQ -->|"binds and processes"| mRNA_binding
HNRNPQ -->|"regulates"| cofilin_translation
mRNA_binding -->|"controls"| RNA_metabolism
cofilin_translation -->|"produces"| cofilin
cofilin -->|"regulates"| actin_dynamics
actin_dynamics -->|"maintains"| spine_morphology
spine_morphology -->|"enables"| synaptic_plasticity
HNRNPQ -->|"localizes to"| RNA_granules
RNA_granules -->|"forms under stress"| stress_granules
stress_granules -->|"promotes"| protein_aggregation
RNA_metabolism -->|"dysfunction leads to"| neuronal_dysfunction
protein_aggregation -->|"causes"| neuronal_dysfunction
neuronal_dysfunction -->|"progresses to"| neurodegeneration
neurodegeneration -->|"manifests as"| ALS
neurodegeneration -->|"manifests as"| FTD
style HNRNPQ fill:#1a3a4a,stroke:#4fc3f7
style cofilin fill:#2a1a3a,stroke:#ce93d8
style synaptic_plasticity fill:#1a3a2a,stroke:#81c784
style actin_dynamics fill:#1a3a2a,stroke:#81c784
style protein_aggregation fill:#3a1a1a,stroke:#ef5350
style neuronal_dysfunction fill:#3a1a1a,stroke:#ef5350
style neurodegeneration fill:#3a1a1a,stroke:#ef5350
style ALS fill:#3a2a1a,stroke:#ffa726
style FTD fill:#3a2a1a,stroke:#ffa726| Target | Relation | Type | Str |
|---|---|---|---|
| cofilin translation | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HNRNPQ in their description or question text
No additional research found