gene

HNRNPU1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HNRNPU1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive page on HNRNPU1 (Heterogeneous Nuclear Ribonucleoprotein U), a nuclear matrix protein involved in RNA processing, DNA repair, and transcription regulation, implicated in neurodegeneration, epilepsy, and autism spectrum disorders.

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🧬 Gene Info

Gene Symbol	HNRNPU1
Aliases	Heterogeneous Nuclear Ribonucleoprotein U
Chromosome	1q44
Function	encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of RNA-binding proteins.
Primary Expression	most other tissues at moderate to high levels
Molecular Weight	120 kDa
Amino Acids	825 aa
Exons	14
Ensembl ID	ENSG00000147689
GeneCards	HNRNPU1
Human Protein Atlas	HNRNPU1
Brain	High expression throughout the brain, with particular abundance in neurons of the cortex, hippocampus, and cerebellum.
Spinal Cord	Significant expression in motor neurons.
Systemic Tissues	Expressed in most other tissues at moderate to high levels.
Cellular Localization	Predominantly nuclear, associated with the nuclear matrix.
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HNRNPU1 Gene

gene · 1703 words

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Pathway Diagram

graph TD
    HNRNPU1["HNRNPU1"]
    neurodegeneration["neurodegeneration"]
    HNRNPU1 -->|"implicated_in"| neurodegeneration
    style HNRNPU1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HNRNPU1 in their description or question text

No additional research found