Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HNRNPUL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HNRNPUL2 |
| Chromosome | 19q13.43 |
| Function | is a nuclear matrix protein that belongs to the hnRNP U family. |
| Primary Expression | human tissues, with particularly high expression in neuronal nuclei |
| Amino Acids | 640 aa |
| GeneCards | HNRNPUL2 |
| Human Protein Atlas | HNRNPUL2 |
| N-terminal SAP domain | Involved in DNA/RNA binding and nuclear matrix attachment |
| Central glycine-rich region | Facilitates protein-protein interactions |
| C-terminal RGG repeats | RNA-binding motifs involved in RNA granule formation |
| Alternative splicing regulation | Modulates inclusion or exclusion of specific exons |
| RNA stability | Binds to specific RNA sequences to regulate mRNA half-life |
| RNA transport | Facilitates transport of mRNAs from nucleus to cytoplasm |
| Brain | Particularly in the cerebral cortex, hippocampus, and spinal cord motor neurons |
| Testis | High expression in spermatogonia and spermatocytes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HNRNPUL2["HNRNPUL2"]
neurodegeneration["neurodegeneration"]
HNRNPUL2 -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HNRNPUL2 in their description or question text
No additional research found