gene

HRH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HRH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

HRH2 is a gene implicated in neurodegeneration research. Key relationships include: upregulates, regulates, implicated in. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HRH2
Full Name	HRH2 — Histamine Receptor H2
Aliases	Histamine Receptor H2
Chromosome	5q35.2
Protein Type	Gene
Function	encodes a 391-amino acid protein that signals primarily through Gs proteins, leading to increased intracellular cAMP levels.
Amino Acids	391 aa
Exons	4
NCBI Gene ID	3374
GeneCards	HRH2
Human Protein Atlas	HRH2
Transmembrane domains	Seven α-helices that traverse the plasma membrane
Ligand-binding pocket	Formed by TM3, TM5, TM6, and TM7
G-protein coupling domain	Located on intracellular loops 2 and 3
Phosphorylation sites	Serine and threonine residues on the C-terminus for receptor regulation
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HRH2 Gene — Histamine Receptor H2

gene · 1850 words

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Pathway Diagram

graph TD
    HRH2["HRH2"]
    cellular_prion_protein["cellular prion protein"]
    HRH2 -->|"regulates"| cellular_prion_protein
    naringenin_chalcone["naringenin chalcone"]
    HRH2 -->|"binds"| naringenin_chalcone
    ATP4A["ATP4A"]
    HRH2 -->|"upregulates"| ATP4A
    CLIC6["CLIC6"]
    HRH2 -->|"upregulates"| CLIC6
    KCNQ1["KCNQ1"]
    HRH2 -->|"upregulates"| KCNQ1
    AQP4["AQP4"]
    HRH2 -->|"upregulates"| AQP4
    HDC["HDC"]
    HRH2 -->|"upregulates"| HDC
    CCKBR["CCKBR"]
    HRH2 -->|"upregulates"| CCKBR
    CHIA["CHIA"]
    HRH2 -->|"upregulates"| CHIA
    PGA5["PGA5"]
    HRH2 -->|"upregulates"| PGA5
    GHRL["GHRL"]
    HRH2 -->|"upregulates"| GHRL
    MBOAT4["MBOAT4"]
    HRH2 -->|"upregulates"| MBOAT4
    style HRH2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HRH2 in their description or question text

No additional research found