Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | HSF2 |
| Full Name | Heat Shock Transcription Factor 2 |
| Chromosome | 6q22.31 |
| Protein Type | Transcription Factor |
| Function | ### Heat Shock Protein Regulation |
| Exons | 13 |
| Ensembl ID | ENSG00000125124 |
| GeneCards | HSF2 |
| Human Protein Atlas | HSF2 |
| DNA-binding domain (DBD) | Helix-turn-helix motif for heat shock element recognition |
| Oligomerization domain | Mediates trimerization via hydrophobic heptad repeats (HR-A/B) |
| Regulatory domain | Controls transcriptional activity |
| Transactivation domain | C-terminal region for coactivator recruitment |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HSF2["HSF2"]
neurodegeneration["neurodegeneration"]
HSF2 -->|"implicated_in"| neurodegeneration
style HSF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||