gene

HSPB2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HSPB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	HSPB2
Full Name	Heat Shock Protein Family B (Small) Member 2
Chromosome	22q12.3
Function	is a member of the small heat shock protein (sHSP) family[@sugiyama2000].
Primary Expression	muscle tissues and has been increasingly recognized for its neuroprotective functions in various neurodegenerative diseases[@wang2019]
Molecular Weight	20 kDa
Amino Acids	182 aa
UniProt ID	Q16039
NCBI Gene ID	11079
Ensembl ID	ENSG00000168872
OMIM	604689
GeneCards	HSPB2
Human Protein Atlas	HSPB2
Quaternary Structure	Forms 12-30 subunit oligomers
Dynamic Assembly	Oligomerization is dynamic and regulated by stress conditions
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPB2 — AlphaFold Q16039 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSPB2 Gene (Heat Shock Protein Family B Member 2)

gene · 1701 words

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HSPB2 Protein

protein · 1092 words

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Pathway Diagram

graph TD
    HSPB2["HSPB2"]
    neurodegeneration["neurodegeneration"]
    HSPB2 -->|"implicated_in"| neurodegeneration
    style HSPB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HSPB2 in their description or question text

No additional research found