gene

HSPB7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPB7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Debates

Summary

Page for HSPB7 — Heat Shock Protein Family B7

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🧬 Gene Info

Gene Symbol	HSPB7
Full Name	Heat Shock Protein Beta 7
Chromosome	1p36.23
Function	HSPB7 functions as a molecular chaperone with several key cellular roles:
Molecular Weight	17 kDa
Amino Acids	90 aa
UniProt ID	Q9UQ16
NCBI Gene ID	27128
Ensembl ID	ENSG00173653
OMIM	611383
GeneCards	HSPB7
Human Protein Atlas	HSPB7
Alzheimer's Disease	HSPB7 expression is altered in AD brain tissue, potentially as a compensatory neuroprotective response
Parkinson's Disease	May interact with α-synuclein aggregation pathways
ALS	Some studies report HSPB7 changes in muscle tissue of ALS patients
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPB7 — AlphaFold Q9UQ16 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HSPB7["HSPB7 / cvHSP"] -->|"Small HSP"| Chaperone["Molecular Chaperone"]
    HSPB7 -->|"Prevents"| Aggregation["Protein Aggregation"]
    HSPB7 -->|"Highly expressed in"| Heart["Heart, Skeletal Muscle"]
    HSPB7 -->|"Maintains"| Sarcomere["Sarcomere Integrity"]
    HSPB7 -->|"Interacts with"| BAG3["BAG3"]
    BAG3 -->|"Mediates"| Autophagy["Chaperone-Assisted Autophagy"]
    HSPB7 -.->|"Linked to"| DCM["Dilated Cardiomyopathy"]
    HSPB7 -->|"Protects"| Cytoskeleton["Cytoskeletal Proteins"]

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSPB7 in their description or question text

No additional research found