gene

HTR1E

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HTR1E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for HTR1E — 5-Hydroxytryptamine Receptor 1E

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🧬 Gene Info

Gene Symbol	HTR1E
Full Name	5-Hydroxytryptamine Receptor 1E
Chromosome	6q14.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various brain regions including the frontal cortex, hippocampus, and basal ganglia, areas criti
UniProt ID	P28566
NCBI Gene ID	3354
GeneCards	HTR1E
Human Protein Atlas	HTR1E
G protein coupling	Gi/o-coupled, inhibiting adenylyl cyclase
Signal transduction	Decreases intracellular cAMP levels
Ligand binding	High affinity for serotonin (5-HT) and various serotonergic drugs
Receptor distribution	Prefrontal cortex, hippocampus, basal ganglia, dorsal raphe nucleus
Schizophrenia	Altered 5-HT1E binding has been reported in prefrontal cortex <sup>11</sup>
Migraine	5-HT1E receptors are targeted by serotonergic migraine therapeutics <sup>12</sup>
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HTR1E — AlphaFold P28566 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HTR1E — 5-Hydroxytryptamine Receptor 1E

gene · 604 words

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HTR1E Protein — 5-Hydroxytryptamine Receptor 1E

protein · 1067 words

→

Pathway Diagram

graph TD
    HTR1E["HTR1E"]
    neurodegeneration["neurodegeneration"]
    HTR1E -->|"implicated_in"| neurodegeneration
    style HTR1E fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HTR1E in their description or question text

No additional research found