Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about htr1f: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Gene Symbol | HTR1F |
| Full Name | 5-Hydroxytryptamine Receptor 1F |
| Chromosome | 3p12 |
| Protein Type | Receptor |
| Function | encodes the 5-HT1F serotonin receptor, a Gi/Go-coupled GPCR that inhibits adenylate cyclase activity |
| Primary Expression | the trigeminal ganglion and brain, where it modulates nociception and migraine |
| Molecular Weight | 39 kDa |
| UniProt ID | P30939 |
| NCBI Gene ID | 3354 |
| Ensembl ID | ENSG00000140022 |
| OMIM | 182134 |
| GeneCards | HTR1F |
| Human Protein Atlas | HTR1F |
| N-terminal extracellular domain | Contains conserved disulfide bond |
| Seven transmembrane domains | α-helices connected by three extracellular and three intracellular loops |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["htr1f gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:HTR1F | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:HTR1F | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning htr1f in their description or question text
No additional research found