Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HTR3D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The HTR3D gene encodes the 5-HT3 receptor subunit D, a ligand-gated ion channel component essential for fast serotonergic signaling. This page covers the gene's structure, function, expression, disease associations, and therapeutic relevance.
| Gene Symbol | HTR3D |
| Chromosome | 3q27.1 |
| Protein Type | Channel |
| Function | is a member of the ligand-gated ion channel family that forms part of the 5-HT3 receptor. |
| Primary Expression | specific tissues and form heteromeric receptors with modified properties |
| Amino Acids | 473 aa |
| Ensembl ID | ENSG00000165644 |
| GeneCards | HTR3D |
| Human Protein Atlas | HTR3D |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HTR3D["HTR3D"]
neurodegeneration["neurodegeneration"]
HTR3D -->|"implicated_in"| neurodegeneration
style HTR3D fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||