gene

HTR3E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR3E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The HTR3E gene encodes the 5-HT3 receptor subunit E, an auxiliary subunit that modulates the properties of heteromeric 5-HT3 receptors. This page covers the gene's structure, function, expression, disease associations, and therapeutic relevance.

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🧬 Gene Info

Gene Symbol	HTR3E
Chromosome	3q27.1
Protein Type	Receptor
Function	encodes an auxiliary subunit of the 5-HT3 receptor, a ligand-gated ion channel that mediates fast serotonergic signaling.
Subcellular Localization	Can influence the subcellular distribution of receptors
Amino Acids	465 aa
Ensembl ID	ENSG00000181191
GeneCards	HTR3E
Human Protein Atlas	HTR3E
Agonist Affinity	May alter the affinity for serotonin and other agonists
Antagonist Sensitivity	Different sensitivity to selective antagonists
Allosteric Modulation	Unique binding sites for allosteric modulators
Single-Channel Conductance	Alters channel conductance properties
Desensitization Kinetics	Modulates the rate and extent of receptor desensitization
Recovery from Desensitization	Affects the time course of receptor recovery
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HTR3E Gene

gene · 1758 words

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Pathway Diagram

graph TD
    HTR3E["HTR3E"]
    neurodegeneration["neurodegeneration"]
    HTR3E -->|"implicated_in"| neurodegeneration
    style HTR3E fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HTR3E in their description or question text

No additional research found