protein

HTR5APROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR5APROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The 5-HT5A receptor is a Gi/o protein-coupled serotonin receptor that inhibits adenylyl cyclase, reducing intracellular cAMP production.

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🔬 Protein Info

Gene Symbol	HTR5APROTEIN
Chromosome	7q36.3
Protein Type	Receptor
Function	is a Gi/o protein-coupled serotonin receptor that inhibits adenylyl cyclase, reducing intracellular cAMP production.
Primary Expression	trigeminal pain pathways, suggesting a role in migraine pathophysiology
Subcellular Localization	</b></td><td>Cell membrane, plasma membrane</td></tr>
Molecular Weight	42 kDa
Amino Acids	357 aa
GeneCards	HTR5APROTEIN
Human Protein Atlas	HTR5APROTEIN
Sleep induction	Activation of 5-HT5A receptors promotes sleep onset and increases total sleep time
Sleep consolidation	The receptor helps synchronize sleep-wake cycles through interactions with the suprachiasmatic nucleus
REM sleep modulation	Evidence suggests 5-HT5A modulates REM sleep patterns
Circadian rhythm	Receptor expression shows circadian variation, peaking during sleep-relevant hours
Learning and memory	Receptor activation influences hippocampal-dependent learning tasks
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

htr5a-protein

protein · 934 words

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Pathway Diagram

graph TD
    HTR5APROTEIN["HTR5APROTEIN"]
    neurodegeneration["neurodegeneration"]
    HTR5APROTEIN -->|"implicated_in"| neurodegeneration
    style HTR5APROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning HTR5APROTEIN in their description or question text

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