protein

HUNTINGTIN_PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HUNTINGTIN_PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Huntingtin Protein

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🔬 Protein Info

Gene Symbol	HUNTINGTIN_PROTEIN
Function	Huntingtin is essential for embryonic development and has multiple functions in the adult nervous system[1]:
Amino Acids	144 aa
N-terminal domain (1-90 aa)	Contains the polyglutamine (polyQ) tract (CAG repeat, normally 10-35)
HEAT repeat domain (90-1,700 aa)	~23 HEAT repeats; mediates protein-protein interactions
Bridge region (1,700-2,200 aa)	Flexible linker with multiple proline-rich motifs
C-terminal domain (2,200-3,144 aa)	Contains additional HEAT repeats and regulatory sequences
Phosphorylation	At Ser-16, Ser-421, Thr-47 (neuroprotective)
Acetylation	At Lys-44, Lys-555 (affects aggregation and clearance)
Sumoylation	Multiple sites
Palmitoylation	At Cys-214 (membrane association)
Proteolytic cleavage	By caspases, calpains generating toxic N-terminal fragments
Axonal transport	Associates with dynein/dynactin and kinesin for vesicle movement
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Huntingtin Protein

protein · 712 words

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Pathway Diagram

graph TD
    HUNTINGTIN_PROTEIN["HUNTINGTIN_PROTEIN"]
    neurodegeneration["neurodegeneration"]
    HUNTINGTIN_PROTEIN -->|"implicated_in"| neurodegeneration
    style HUNTINGTIN_PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning HUNTINGTIN_PROTEIN in their description or question text

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