concept

HUNTINGTON'S

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUNTINGTON'S: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

310Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HUNTINGTON'S is a concept in neurodegeneration research. Key relationships include: co discussed, causes, expressed in. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 61 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HUNTINGTON'S
Key Genes/Proteins	PARKIN, STING
Related Diseases	PARKINSON, PARKINSON'S, PARKINSON'S DISEASE, ALZHEIMER, ALZHEIMER'S

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HUNTINGTON_S["<b>HUNTINGTON'S</b>"]
    HUNTINGTON_S -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    HUNTINGTON_S -->|"regulates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    HUNTINGTON_S -->|"expressed in"| PARKIN["PARKIN"]
    HUNTINGTON_S -->|"expressed in"| PARKINSON["PARKINSON"]
    HUNTINGTON_S -->|"expressed in"| PARKINSON_S["PARKINSON'S"]
    HUNTINGTON_S -->|"causes"| PRION_DISEASE["PRION DISEASE"]
    HUNTINGTON_S -->|"treats"| NEUROPATHY["NEUROPATHY"]
    HUNTINGTON_S -->|"contributes to"| NEURODEGENERATION["NEURODEGENERATION"]
    ALZHEIMER["ALZHEIMER"] -->|"expressed in"| HUNTINGTON_S
    ALZHEIMER_S["ALZHEIMER'S"] -->|"expressed in"| HUNTINGTON_S
    ALS["ALS"] -->|"treats"| HUNTINGTON_S
    HUNTINGTON["HUNTINGTON"] -->|"treats"| HUNTINGTON_S
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"causes"| HUNTINGTON_S
    FERROPTOSIS["FERROPTOSIS"] -->|"contributes to"| HUNTINGTON_S
    AMPK["AMPK"] -->|"regulates"| HUNTINGTON_S

Outgoing (72)

Target	Relation	Type	Str
NEURONS	causes_injury_to	cell_type	0.80
PARKIN	regulates	gene	0.65
PARKINSON	regulates	disease	0.65
PARKINSON'S	regulates	disease	0.65
PARKINSON'S DISEASE	regulates	disease	0.65
PARKIN	causes	gene	0.65
PARKINSON	causes	disease	0.65
PARKINSON'S	causes	disease	0.65
PARKINSON'S DISEASE	causes	disease	0.65
STING	activates	gene	0.65
STING	interacts_with	gene	0.65
SLC6A3	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
PARKIN	expressed_in	gene	0.60
PARKINSON	expressed_in	disease	0.60
PARKINSON'S	expressed_in	disease	0.60
PRION DISEASE	causes	disease	0.60
NEUROPATHY	treats	disease	0.60
NEURODEGENERATION	contributes_to	disease	0.60
NEURODEGENERATION	causes	disease	0.60
SCHIZOPHRENIA	associated_with	disease	0.60
STROKE	associated_with	disease	0.60
NEURON	causes	cell_type	0.60
NEURONS	causes	cell_type	0.60
PINK1	causes	gene	0.60
STING	contributes_to	gene	0.60
SYNUCLEIN	interacts_with	concept	0.50
CEREBROSPINAL FLUID	interacts_with	concept	0.50
Pain	associated_with	disease	0.50
PERICYTES	interacts_with	concept	0.50
TEMPORAL LOBE	associated_with	concept	0.50
cGAS-STING pathway	interacts_with	pathway	0.50
NEURODEGENERATIVE DISEASE	expressed_in	concept	0.50
STAU1	expressed_in	concept	0.50
AADC	associated_with	concept	0.50
NEURODEGENERATIVE DISEASE	causes	concept	0.50
Microrna	activates	pathway	0.50
Proteins	associated_with	protein	0.50
Proteins	protects_against	protein	0.50
SYNUCLEIN	protects_against	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
NEURODEGENERATIVE DISEASE	activates	concept	0.50
Proteins	activates	protein	0.50
STRIATUM	associated_with	concept	0.50
Macular Degeneration	regulates	disease	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
PRION DISEASE	co_discussed	disease	0.40
PARKIN	co_discussed	gene	0.40
PARKINSON	co_discussed	disease	0.40

Incoming (238)

Source	Relation	Type	Str
ALZHEIMER	activates	disease	0.65
ALZHEIMER'S	activates	disease	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
ALS	associated_with	disease	0.65
HUNTINGTON	causes	disease	0.65
CGAS	interacts_with	gene	0.65
BASAL GANGLIA	expressed_in	brain_region	0.65
ALZHEIMER	expressed_in	disease	0.60
ALZHEIMER'S	expressed_in	disease	0.60
ALS	treats	disease	0.60
HUNTINGTON	treats	disease	0.60
ALZHEIMER	causes	disease	0.60
ALZHEIMER'S	causes	disease	0.60
ALZHEIMER'S DISEASE	causes	disease	0.60
AMPK	regulates	gene	0.60
GLIOMA	associated_with	disease	0.60
ALZHEIMER	treats	disease	0.60
ALZHEIMER'S	treats	disease	0.60
ALZHEIMER'S DISEASE	treats	disease	0.60
HTT	causes	gene	0.60
HTT	interacts_with	gene	0.60
HUNTINGTON	contributes_to	disease	0.60
HSP90	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	contributes_to	disease	0.60
FUS	mediates	gene	0.60
SNCA	interacts_with	gene	0.50
TUBB4B	interacts_with	gene	0.50
NDUFA9	interacts_with	gene	0.50
TUBB3	interacts_with	gene	0.50
SLC6A3	interacts_with	gene	0.50
TUBB	interacts_with	gene	0.50
Prion	interacts_with	protein	0.50
ALZHEIMER	interacts_with	gene	0.50
HUNTINGTON	interacts_with	gene	0.50
NEURODEGENERATIVE DISORDERS	interacts_with	concept	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
IGF2	interacts_with	gene	0.50
PARKINSON	interacts_with	gene	0.50
amyotrophic lateral sclerosis	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
Parkinson's Disease	interacts_with	disease	0.50
HUNTINGTON'S DISEASE	interacts_with	concept	0.50
PARKINSON'S	interacts_with	concept	0.50
Neuroinflammation	regulates	process	0.50
Prion	regulates	protein	0.50
inflammation	regulates	pathway	0.50
ALZHEIMER	regulates	gene	0.50
PARKINSON	regulates	gene	0.50
DEMENTIA	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HUNTINGTON'S

Understanding Entity Pages

Summary

Wiki Pages (20)

Novel Therapy Index

Parkinson's Disease

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

NPM1 Gene

Neurons — Cell Type Hierarchy

neuroinflammation

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

Growth Factor Therapies

Circadian Rhythm in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Oligodendrocytes