gene

IARS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IARS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

IARS1 (Isoleucyl-tRNA Synthetase 1) - Aminoacyl-tRNA synthetase involved in protein synthesis, mitochondrial function, and implicated in neurodevelopmental disorders and neurodegeneration

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🧬 Gene Info

Gene Symbol	IARS1
Full Name	Isoleucyl-tRNA Synthetase 1
Aliases	IARS, IleRS, IARS1
Chromosome	9q21.11
Protein Type	Enzyme
Function	encodes a crucial enzyme in protein synthesis, catalyzing the attachment of L-isoleucine to its cognate tRNA.
Molecular Weight	~140 kDa
Amino Acids	260 aa
UniProt ID	P52292
NCBI Gene ID	3376
Ensembl ID	ENSG00000115539
OMIM	600709
GeneCards	IARS1
Human Protein Atlas	IARS1
Gene Name	Isoleucyl-tRNA Synthetase 1
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IARS1 — AlphaFold P52292 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IARS1 — Isoleucyl-tRNA Synthetase 1

gene · 1847 words

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Genes

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Pathway Diagram

graph TD
    IARS1["IARS1"]
    neurodegeneration["neurodegeneration"]
    IARS1 -->|"implicated_in"| neurodegeneration
    style IARS1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found