protein

IBA57

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IBA57: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for IBA57 Protein

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🔬 Protein Info

Gene Symbol	IBA57
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	tissues with high mitochondrial content:
Molecular Weight	40 kDa
Ensembl ID	ENSG00000169189
GeneCards	IBA57
Human Protein Atlas	IBA57
Fe-S Cluster Biogenesis	Essential cofactor for ISCA2 and ISCA1 in the mitochondrial Fe-S cluster (ISC) assembly pathway[@beilschmidt2017]
Mitochondrial Electron Transport Chain	Required for proper assembly and function of Complex I (NADH:ubiquinone oxidoreductase), Complex II (succinate dehydrogenase), and Complex III (cytochrome bc1 complex)
Iron-Sulfur Protein Maturation	Catalyzes insertion of 4Fe-4S clusters into specific target proteins including aconitase, ferredoxin, and respiratory complex subunits
Mitochondrial DNA Maintenance	Indirectly supports mtDNA replication and transcription through Fe-S protein function
Cellular Iron Homeostasis	Regulates mitochondrial iron uptake and storage to prevent oxidative damage
Brain	High expression in cerebral cortex, hippocampus, basal ganglia, and spinal cord motor neurons
Skeletal Muscle	Essential for mitochondrial function in muscle fibers
Heart	Cardiac muscle relies heavily on oxidative phosphorylation
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IBA57 Gene

gene · 653 words

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IBA57 Protein

protein · 602 words

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Pathway Diagram

graph TD
    IBA57["IBA57"]
    neurodegeneration["neurodegeneration"]
    IBA57 -->|"implicated_in"| neurodegeneration
    style IBA57 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning IBA57 in their description or question text

No additional research found