Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IHH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | IHH |
| Full Name | Indian Hedgehog |
| Chromosome | 2q35 |
| Function | is a critical signaling molecule that plays essential roles in embryonic development, particularly in bone formation, chondrocyte differentiation, and neurogenesis. |
| Molecular Weight | 45 kDa |
| Amino Acids | 426 aa |
| Exons | 3 |
| Ensembl ID | ENSG00000163501 |
| GeneCards | IHH |
| Human Protein Atlas | IHH |
| Chondrocyte proliferation | IHH promotes hypertrophic chondrocyte proliferation |
| Bone collar formation | Initiates periosteal bone formation |
| Growth plate organization | Critical for growth plate structure |
| Osteoblast differentiation | Promotes osteoblast differentiation |
| Proliferation | IHH stimulates chondrocyte proliferation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IHH["IHH"]
neurodegeneration["neurodegeneration"]
IHH -->|"implicated_in"| neurodegeneration
style IHH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||