Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IKKBETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | IKBKB |
| Full Name | Inhibitor of Nuclear Factor Kappa B Kinase Subunit Beta |
| Chromosome | 8p11.21 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 87 kDa |
| Amino Acids | 756 aa |
| Exons | 22 |
| Pathways | NF-κB, NF-κB signaling |
| UniProt ID | O14920 |
| NCBI Gene ID | 3551 |
| Ensembl ID | ENSG00000105220 |
| GeneCards | IKBKB |
| Human Protein Atlas | IKBKB |
| Alternate Symbols | IKKβ, IKK2 |
| RefSeq mRNA | NM_001190 |
| Associated Diseases | Als, Autoimmune, Ms, Rheumatoid Arthritis |
| Interactions | GAIN, MTOR, CHUK, IL6, LC3, PRDX6 |
| KG Connections | 154 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
IKKBETA["IKKBETA"]
neurodegeneration["neurodegeneration"]
IKKBETA -->|"implicated_in"| neurodegeneration
style IKKBETA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||