gene

IL17C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL17C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

6Outgoing

1Incoming

Summary

Comprehensive analysis of Interleukin-17C (IL17C) gene, its role in neuroinflammation, immune signaling, and implications for neurodegenerative diseases including Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	IL17C
Full Name	Interleukin 17C
Chromosome	5q33.1
Function	is a distinctive member of the IL-17 cytokine family that plays important roles in mucosal immunity, epithelial defense, and neuroinflammatory processes.
Molecular Weight	~25 kDa
Amino Acids	219 aa
Pathways	NF-κB
UniProt ID	Q9P0M4
NCBI Gene ID	151306
Ensembl ID	ENSG00000109339
OMIM	607246
GeneCards	IL17C
Human Protein Atlas	IL17C
Encoded Protein	Interleukin-17C
Protein Length	219 amino acids
Associated Diseases	Autoimmunity
Known Drugs/Compounds	DUPILUMAB
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL17C — AlphaFold Q9P0M4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL17C["<b>IL17C</b>"]
    IL_6["IL-6"]
    IL17C -->|"upregulates"| IL_6
    IL_8["IL-8"]
    IL17C -->|"upregulates"| IL_8
    TGF_1["TGFbeta1"]
    IL17C -->|"upregulates"| TGF_1
    Inflammation["Inflammation"]
    IL17C -->|"associated with"| Inflammation
    Autoimmunity{"Autoimmunity"}
    IL17C -->|"associated with"| Autoimmunity
    Bacterial_Infection["Bacterial Infection"]
    IL17C -->|"protects against"| Bacterial_Infection
    IL17RA["IL17RA"]
    IL17C -->|"binds"| IL17RA
    IL17RE["IL17RE"]
    IL17C -->|"binds"| IL17RE
    neurodegeneration["neurodegeneration"]
    IL17C -->|"implicated in"| neurodegeneration
    DUPILUMAB["DUPILUMAB"]
    DUPILUMAB -->|"inhibits"| IL17C
    style IL17C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
TGFβ1	upregulates	entity	0.80
Autoimmunity	associated_with	disease	0.80
IL-6	upregulates	entity	0.80
IL-8	upregulates	entity	0.80
IL17RA	binds	receptor	0.70
IL17RE	binds	receptor	0.70

Incoming (1)

Source	Relation	Type	Str
DUPILUMAB	inhibits	drug	0.64

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found