gene

IL21

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about IL21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for IL21 Gene

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🧬 Gene Info

Gene Symbol	IL21
Chromosome	4q27
Function	is a potent immunomodulatory cytokine belonging to the common gamma-chain receptor family, encoded by the IL21 gene located on chromosome 4q27 [1](https://www.
Primary Expression	multiple cell types: - Lymphocytes: B cells, T cells, NK cells - Myeloid cells: Macrophages, dendritic cells - Non-hematopoietic: Some epi
Pathways	JAK-STAT Pathway, PI3K, MAPK pathway, TGF-β
Ensembl ID	ENSG00000138618
GeneCards	IL21
Human Protein Atlas	IL21
Lymphocytes	B cells, T cells, NK cells
Myeloid cells	Macrophages, dendritic cells
Non-hematopoietic	Some epithelial and stromal cells 6
JAK1 and JAK3	Associated with IL21R and γc chains
STAT3	Primary transcription factor activated
STAT5	Also activated in some cell types
PI3K-AKT and MAPK pathways	Contributing to cell survival and proliferation 7
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL21

gene · 1032 words

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Pathway Diagram

graph TD
    IL21["IL21"]
    neurodegeneration["neurodegeneration"]
    IL21 -->|"implicated_in"| neurodegeneration
    style IL21 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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