gene

INNPP5D

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about INNPP5D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

INPP5D Gene

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🧬 Gene Info

Gene Symbol	INNPP5D
Full Name	Inositol Polyphosphate-5-Phosphatase D
Chromosome	2q37.1
Function	INPP5D encodes SHIP1 (Src homology 2 domain-containing inositol phosphatase 1), a phosphatase that converts PIP3 to PI(3,4)P2, thereby negatively regulating PI3K/Akt signaling.
Primary Expression	hematopoietic cells, including microglia in the brain
Amino Acids	1190 aa
Exons	13
UniProt ID	Q13596
NCBI Gene ID	3635
Ensembl ID	ENSG00000168918
OMIM	601582
GeneCards	INNPP5D
Human Protein Atlas	INNPP5D
Phosphatase domain	catalytic domain with HCX5R motif common to inositol phosphatases
C2 domain	involved in lipid binding and membrane localization
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: INNPP5D — AlphaFold Q13596 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

INPP5D Gene

gene · 880 words

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Pathway Diagram

graph TD
    INNPP5D["INNPP5D"]
    neurodegeneration["neurodegeneration"]
    INNPP5D -->|"implicated_in"| neurodegeneration
    style INNPP5D fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning INNPP5D in their description or question text

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