protein

IP3R1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IP3R1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

IP3 Receptor 1 Protein

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🔬 Protein Info

Gene Symbol	IP3R1
Protein Family	IP3 receptor family
Protein Type	Channel
Function	ITPR1 (IP3R1) is an intracellular calcium release channel on the endoplasmic reticulum.
Primary Expression	cerebellar Purkinje cells and hippocampal neurons
Molecular Weight	313 kDa
UniProt ID	Q14543
GeneCards	IP3R1
Human Protein Atlas	IP3R1
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: IP3R1 — AlphaFold Q14543 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IP3 Receptor 1 Protein

protein · 631 words

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Pathway Diagram

graph TD
    IP3R1["IP3 Receptor 1"]
    IP3["Inositol 1,4,5-trisphosphate"]
    PLC["Phospholipase C"]
    DAG["Diacylglycerol"]
    PKC["Protein Kinase C"]
    ER["Endoplasmic Reticulum"]
    CA2["Cytoplasmic Ca2+"]
    CALCINEURIN["Calcineurin"]
    CREB["CREB Transcription"]
    ER_STRESS["ER Stress"]
    UPR["Unfolded Protein Response"]
    APOPTOSIS["Neuronal Apoptosis"]
    SYNCRIP["SYNCRIP"]
    MITOCHONDRIA["Mitochondrial Dysfunction"]
    NEURODEGENERATION["Neurodegeneration"]
    
    PLC -->|"generates"| IP3
    PLC -->|"generates"| DAG
    IP3 -->|"binds and activates"| IP3R1
    IP3R1 -->|"releases Ca2+ from"| ER
    ER -->|"Ca2+ efflux"| CA2
    CA2 -->|"activates"| CALCINEURIN
    CA2 -->|"activates"| PKC
    CALCINEURIN -->|"promotes"| CREB
    CA2 -->|"overload causes"| ER_STRESS
    ER_STRESS -->|"triggers"| UPR
    UPR -->|"chronic activation leads to"| APOPTOSIS
    CA2 -->|"disrupts"| MITOCHONDRIA
    MITOCHONDRIA -->|"contributes to"| APOPTOSIS
    APOPTOSIS -->|"drives"| NEURODEGENERATION
    SYNCRIP -->|"co-expressed with"| IP3R1
    
    style IP3R1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style CREB fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style CALCINEURIN fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style ER_STRESS fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style APOPTOSIS fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style NEURODEGENERATION fill:#3a2a1a,stroke:#ffa726,stroke-width:3px
    style SYNCRIP fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style MITOCHONDRIA fill:#3a1a1a,stroke:#ef5350,stroke-width:2px

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
SYNCRIP	co_expressed_with	protein	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IP3R1 in their description or question text

No additional research found