IREB2

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolIREB2
Nameiron responsive element binding protein 2
Typeprotein-coding
Sourcemygene

Summary

The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is

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