protein

ITPR1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITPR1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ITPR1 is a large tetrameric channel protein, with each subunit comprising approximately 2,700 amino acids and a molecular weight of about 313 kDa[@foskett2007].

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🔬 Protein Info

Gene Symbol	ITPR1PROTEIN
Full Name	Inositol 1,4,5-Trisphosphate Receptor Type 1
Chromosome	3p26
Protein Type	Channel
Function	is a ligand-gated calcium release channel localized to the endoplasmic reticulum (ER) membrane.
Primary Expression	Cerebellum, Cortex, Hippocampus, Basal ganglia
Subcellular Localization	to the endoplasmic reticulum (ER) membrane
Molecular Weight	313 kDa
Amino Acids	700 aa
UniProt ID	Q14643
NCBI Gene ID	3708
GeneCards	ITPR1PROTEIN
Human Protein Atlas	ITPR1PROTEIN
Associated Diseases	Diabetes, stroke
KG Connections	30 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ITPR1PROTEIN — AlphaFold Q14643 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

itpr1-protein

protein · 1885 words

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Pathway Diagram

graph TD
    ITPR1PROTEIN["ITPR1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ITPR1PROTEIN -->|"implicated_in"| neurodegeneration
    style ITPR1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ITPR1PROTEIN in their description or question text

No additional research found