Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KARS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KARS1 - Lysyl-tRNA synthetase 1 with roles in protein synthesis, mitochondrial function, and neurodegeneration
| Gene Symbol | KARS1 |
| Protein Type | Enzyme |
| Function | encodes a crucial enzyme for protein synthesis, catalyzing the attachment of lysine to its cognate tRNA molecule during translation [1](https://pubmed. |
| Amino Acids | 622 aa |
| Ensembl ID | ENSG00000013375 |
| GeneCards | KARS1 |
| Human Protein Atlas | KARS1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KARS1["KARS1"]
neurodegeneration["neurodegeneration"]
KARS1 -->|"implicated_in"| neurodegeneration
style KARS1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity