Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNC2 (Kv3.2) is a voltage-gated potassium channel critical for high-frequency neuronal firing. Dysfunction contributes to neurodegenerative processes through impaired neuronal excitability, particularly in dopaminergic and GABAergic neurons.
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| Gene Symbol | KCNC2 |
| Full Name | Potassium Voltage-Gated Channel Subfamily C Member 2 (Kv3.2) |
| Aliases | Kv3.2 |
| Chromosome | 12q13.3 |
| Protein Type | Gene |
| Function | is a voltage-gated potassium channel that plays a critical role in neuronal excitability, particularly in neurons that fire at high frequencies. |
| Primary Expression | peripheral tissues including the heart, skeletal muscle, and pancreas |
| Amino Acids | 638 aa |
| Exons | 18 |
| GeneCards | KCNC2 |
| Human Protein Atlas | KCNC2 |
| Substantia nigra pars compacta (SNc) | High expression in dopaminergic neurons |
| Hippocampus | Expression in CA1-CA3 pyramidal cells and interneurons |
| Cerebral cortex | Layer III-V pyramidal neurons and parvalbumin-positive interneurons |
| Cerebellar granule cells | High expression in excitatory cerebellar neurons |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KCNC2["KCNC2"]
neurodegeneration["neurodegeneration"]
KCNC2 -->|"implicated_in"| neurodegeneration
style KCNC2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning KCNC2 in their description or question text
No additional research found