Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KCNC3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | High in cerebellar Purkinje cells, inferior olive neurons, and thalamic relay neurons |
| GeneCards | KCNC3 |
| Human Protein Atlas | KCNC3 |
| Channel Type | Voltage-gated potassium (Kv) channel |
| Subunit | Kv3.3 (alpha subunit) |
| Tetrameric assembly | Forms functional channels as tetramers |
| Kv3.3 modulators | 药物 that enhance channel function |
| Gene therapy | AAV-delivered functional KCNC3 |
| Symptomatic treatment | Physical therapy, speech therapy, assistive devices |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KCNC3["KCNC3"]
neurodegeneration["neurodegeneration"]
KCNC3 -->|"implicated_in"| neurodegeneration
style KCNC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KCNC3 in their description or question text
No additional research found