gene

KCNG3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KCNG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Potassium voltage-gated channel modulator gene KCNG3

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🧬 Gene Info

Gene Symbol	KCNG3
Full Name	Potassium Voltage-Gated Channel Modulator Subfamily G Member 3
Chromosome	2p25.2
Function	KCNG3 encodes the Kv6.3 (KCNG3) potassium channel subunit, which functions as a regulatory subunit that modulates the activity of voltage-gated potassium (Kv) channels
Primary Expression	cerebellar and basal ganglia regions
Amino Acids	436 aa
UniProt ID	Q9Y667
NCBI Gene ID	170302
Ensembl ID	ENSG00000171056
GeneCards	KCNG3
Human Protein Atlas	KCNG3
N-terminal domain	Contains the tetramerization domain (T1) responsible for subunit assembly
S1-S6 transmembrane segments	Characteristic of voltage-gated ion channels
Voltage sensor domain (S1-S4)	Detects membrane potential changes
Pore domain (S5-S6)	Forms the ion selectivity filter
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNG3 — AlphaFold Q9Y667 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNG3 Gene

gene · 952 words

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Pathway Diagram

graph TD
    KCNG3["KCNG3"]
    neurodegeneration["neurodegeneration"]
    KCNG3 -->|"implicated_in"| neurodegeneration
    style KCNG3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning KCNG3 in their description or question text

No additional research found