gene

KCNH4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KCNH4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Potassium voltage-gated channel gene KCNH4 (EAG1-like)

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🧬 Gene Info

Gene Symbol	KCNH4
Full Name	Potassium Voltage-Gated Channel Subfamily H Member 4
Aliases	EAG1-like
Chromosome	17q21.2
Protein Type	Channel
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the central nervous system, with particularly high expression in the brain[@shi2014][@ludwig2000]
Amino Acids	962 aa
UniProt ID	Q9Y4X5
NCBI Gene ID	9312
Ensembl ID	ENSG00000155636
GeneCards	KCNH4
Human Protein Atlas	KCNH4
Resting membrane potential maintenance	Contributes to the outward K+ current that stabilizes the resting membrane potential
Action potential repolarization	Helps terminate action potentials by providing outward current during repolarization
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNH4 — AlphaFold Q9Y4X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNH4 Gene

gene · 1105 words

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Pathway Diagram

flowchart TD
    A["Upstream Regulators"] --> B["KCNH4"]
    B --> C["Molecular Mechanism"]
    C --> D["Cellular Effects"]
    D --> E["Pathological Consequences"]

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning KCNH4 in their description or question text

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