gene

KCNH5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNH5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Potassium voltage-gated channel gene KCNH5 (EAG2)

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	KCNH5
Chromosome	14q23.1
Protein Type	Gene
Function	encodes a protein of 989 amino acids forming the core alpha subunit of the EAG2 potassium channel.
Primary Expression	striatal neurons
Amino Acids	989 aa
Exons	16
GeneCards	KCNH5
Human Protein Atlas	KCNH5
N-terminal Per-Arnt-Sim (PAS) domain	Senses voltage and redox state
Voltage sensor domain (VSD)	Segments S1-S4 detect membrane potential changes
Pore domain	Segments S5-S6 form the K+ selectivity filter
Leucine zipper motif	Facilitates tetramerization
Tetrameric assembly	Four alpha subunits form the pore
Auxiliary subunits	May associate with beta subunits
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNH5 Gene

gene · 1161 words

→

Pathway Diagram

graph TD
    KCNH5["KCNH5"]
    neurodegeneration["neurodegeneration"]
    KCNH5 -->|"implicated_in"| neurodegeneration
    style KCNH5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNH5 in their description or question text

No additional research found