gene

KCNH6

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KCNH6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	KCNH6
Aliases	ERG2 Potassium Channel
Chromosome	17q24
Protein Type	Gene
Function	is a member of the voltage-gated potassium channel family belonging to the KCNH (ether-à-go-go-related) subfamily.
Primary Expression	gastric and intestinal smooth muscle, where it regulates gastric motility and intestinal peristalsis
Molecular Weight	99 kDa
Amino Acids	979 aa
Exons	17
UniProt ID	Q9H5Y9
NCBI Gene ID	27151
GeneCards	KCNH6
Human Protein Atlas	KCNH6
Phosphorylation	PKA and PKC phosphorylation can modulate KCNH6 activity
Protein interactions	Interactions with regulatory proteins can affect channel trafficking and function
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNH6 — AlphaFold Q9H5Y9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNH6 (Potassium Voltage-Gated Channel Subfamily H Member 6)

gene · 2029 words

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KCNH6 Protein (ERG2 Potassium Channel)

protein · 651 words

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Pathway Diagram

graph TD
    KCNH6["KCNH6"]
    neurodegeneration["neurodegeneration"]
    KCNH6 -->|"implicated_in"| neurodegeneration
    style KCNH6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning KCNH6 in their description or question text

No additional research found