gene

KCNIP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNIP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Potassium Voltage-Gated Channel Interacting Protein 2, a calcium-binding accessory subunit that modulates Kv4 channel function and neuronal excitability in neurodegeneration

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🧬 Gene Info

Gene Symbol	KCNIP2
Full Name	Potassium Voltage-Gated Channel Interacting Protein 2
Chromosome	10q23.3
Protein Family	KCNIP family (EF-hand calcium-binding proteins)
Protein Type	Channel
Function	encodes a calcium-binding protein that serves as an accessory subunit for Kv4 voltage-gated potassium channels.
Primary Expression	ventricular myocardium, where it regulates cardiac transient outward potassium current (Ito) and action potential duration - Brain: Expressed in v
Subcellular Localization	s and functions:
Molecular Weight	~28 kDa
UniProt ID	Q9H0Y9
NCBI Gene ID	30818
Ensembl ID	ENSG00000116096
GeneCards	KCNIP2
Human Protein Atlas	KCNIP2
Encoded Protein	KCNIP2 (KChIP2)
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNIP2 — AlphaFold Q9H0Y9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KCNIP2["KCNIP2"]
    neurodegeneration["neurodegeneration"]
    KCNIP2 -->|"implicated_in"| neurodegeneration
    style KCNIP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity