protein

KCNJ4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNJ4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for KCNJ4 Protein (Kir2.3 Potassium Channel)

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🔬 Protein Info

Gene Symbol	KCNJ4
Full Name	Potassium Inwardly Rectifying Channel Subfamily J Member 4
Aliases	Kir2.3 Potassium Channel
Chromosome	22q13.1
Protein Type	Channel
Function	KCNJ4 (also known as Kir2.3) encodes an inward rectifier potassium channel that plays crucial roles in neuronal excitability, cardiac rhythm, and cellular homeostasis
UniProt ID	P48745
NCBI Gene ID	3765
Ensembl ID	ENSG00000102195
OMIM	600494
GeneCards	KCNJ4
Human Protein Atlas	KCNJ4
Resting membrane potential	Maintains negative resting potential in neurons and cardiomyocytes
Neuronal excitability	Regulates action potential threshold and firing patterns
Potassium homeostasis	Controls intracellular K+ levels
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNJ4 — AlphaFold P48745 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNJ4 — Potassium Inwardly Rectifying Channel Subfamily J Member 4

gene · 1140 words

→

KCNJ4 Protein (Kir2.3 Potassium Channel)

protein · 567 words

→

Pathway Diagram

graph TD
    KCNJ4["KCNJ4"]
    neurodegeneration["neurodegeneration"]
    KCNJ4 -->|"implicated_in"| neurodegeneration
    style KCNJ4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNJ4 in their description or question text

No additional research found