protein

KCNK6PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KCNK6PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	KCNK6PROTEIN
Protein Type	Channel
Function	is a member of the two-pore domain (K2P) potassium channel family.
Subcellular Localization	</strong></td><td>Cell membrane</td></tr>
Molecular Weight	46 kDa
GeneCards	KCNK6PROTEIN
Human Protein Atlas	KCNK6PROTEIN
Four Transmembrane Segments	Unlike most potassium channels that have six transmembrane segments, K2P channels have only four. The pore domains are formed by the loops between transmembrane segments 1-2 and 3-4.
Two Pore Domains	Each subunit contains two pore domains (P1 and P2), and four subunits assemble to form a functional channel with four pore domains arranged around a central ion conduction pathway.
Dimeric Assembly	While four subunits are required for a functional channel, K2P channels form dimers, with each monomer contributing one pore domain to the overall channel structure.
Phosphorylation	Kinases can modulate KCNK6 activity
Glycosylation	Some K2P channels are glycosylated, affecting trafficking and function
Acetylation	May regulate channel activity
Action Potential Threshold	By setting the resting potential, KCNK6 influences the voltage threshold for action potential firing.
Firing Pattern	K2P channels modulate whether neurons fire tonically or exhibit burst firing patterns.
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

kcnk6-protein

protein · 1574 words

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Pathway Diagram

graph TD
    KCNK6PROTEIN["KCNK6PROTEIN"]
    neurodegeneration["neurodegeneration"]
    KCNK6PROTEIN -->|"implicated_in"| neurodegeneration
    style KCNK6PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Research

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