Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIAA0196: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | WASHC5 (formerly KIAA0196) |
| Full Name | WASH Complex Subunit 5 (Strumpellin) |
| Chromosome | 8q24.13 |
| Function | encodes a core component of the WASH complex that regulates endosomal protein sorting and recycling. |
| Amino Acids | 159 aa |
| UniProt ID | Q12768 |
| NCBI Gene ID | 9744 |
| Ensembl ID | ENSG00000104523 |
| OMIM | 610657 |
| Cargo sorting | Enables recycling of cell surface receptors (transferrin receptor, integrins, glucose transporters) from endosomes back to the plasma membrane |
| Retromer cooperation | WASH complex works with the retromer (VPS35) to sort cargo from endosome-to-Golgi and endosome-to-surface pathways |
| Membrane remodeling | Actin-driven tubulation creates recycling tubules from endosomal compartments |
| Receptor trafficking | Required for proper trafficking of signaling receptors in neurons |
| Axonal transport | Long corticospinal axons require efficient endosomal trafficking |
| Synaptic receptor recycling | AMPA and NMDA receptor surface expression depends on endosomal sorting |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KIAA0196["KIAA0196"]
neurodegeneration["neurodegeneration"]
KIAA0196 -->|"implicated_in"| neurodegeneration
style KIAA0196 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KIAA0196 in their description or question text
No additional research found