Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIF17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KIF17 (Kinesin Family Member 17) - Neuronal kinesin motor protein that transports synaptic vesicle precursors, NMDA receptor subunits, and other cargo along microtubules. Critical for synaptic plasticity, memory, and neuronal function.
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| Gene Symbol | KIF17 |
| Full Name | Kinesin Family Member 17 |
| Chromosome | 1p34.2 |
| Function | is a neuronal-specific kinesin motor protein that mediates intracellular transport along microtubules. |
| Subcellular Localization | - Dendritic shafts |
| UniProt ID | KIF17 |
| Ensembl ID | ENSG00000125485 |
| OMIM | 608341 |
| GeneCards | KIF17 |
| Human Protein Atlas | KIF17 |
| Motor domain | At the N-terminus, binds microtubules and hydrolyzes ATP for movement |
| Coiled-coil region | Mediates dimerization |
| Cargo-binding domain | At the C-terminus, binds specific synaptic proteins |
| Dendritic trafficking | Moves cargo within dendrites toward the soma |
| Synapse formation | Participates in synaptogenesis |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KIF17["KIF17"]
neurodegeneration["neurodegeneration"]
KIF17 -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning KIF17 in their description or question text
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