protein

KIF18A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF18A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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Summary

Comprehensive review of KIF18A kinesin motor protein structure, function, and role in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease

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🔬 Protein Info

Gene Symbol	KIF18A
Full Name	Kinesin Family Member 18A
Chromosome	11p14.1
Function	Chromosome Movement: KIF18A moves chromosomes toward the spindle equator through plus-end-directed motility along kinetochore microtubules
Primary Expression	multiple cancer types, making it a promising therapeutic target
Molecular Weight	110 kDa
Amino Acids	725 aa
Exons	17
UniProt ID	[Q8N6S5](https://www.uniprot.org/uniprot/Q8N6S5)
Ensembl ID	ENSG00000121621
GeneCards	KIF18A
Human Protein Atlas	KIF18A
N-terminal motor domain (aa 1-400)	Contains the microtubule-binding site and ATPase activity
Coiled-coil regions (aa 400-700)	Mediates dimerization and cargo binding
C-terminal tail (aa 700-898)	Regulatory functions and microtubule interaction
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KIF18A Gene — Kinesin Family Member 18A

gene · 2577 words

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KIF18A Protein

protein · 1496 words

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Pathway Diagram

graph TD
    KIF18A["KIF18A"]
    neurodegeneration["neurodegeneration"]
    KIF18A -->|"implicated_in"| neurodegeneration
    style KIF18A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KIF18A in their description or question text

No additional research found