Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIF21A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | KIF21A |
| Full Name | Kinesin Family Member 21A |
| Protein Type | Gene |
| Function | KIF21A is a plus-end-directed kinesin that moves along microtubules |
| Primary Expression | neurons and plays critical roles in axonal and dendritic transport, contributing to synaptic function and neuronal viability |
| Amino Acids | 1640 aa |
| GeneCards | KIF21A |
| Human Protein Atlas | KIF21A |
| Motor Domain | KIF21A contains a motor domain that hydrolyzes ATP to generate force for movement along microtubules |
| Cargo Binding | The tail domain binds to various cargoes including vesicles, protein complexes, and organelles |
| Neuronal Specificity | KIF21A expression is enriched in neurons, particularly in axons and dendrites |
| Microtubule Tracking | KIF21A tracks along microtubule plus ends, facilitating long-range transport |
| Axonal Transport Defects | KIF21A dysfunction may contribute to axonal transport deficits observed in AD[@millecamps2013] |
| Amyloid Effects | Aβ oligomers disrupt kinesin-based transport, potentially affecting KIF21A function |
| [Tau](/proteins/tau) Pathology | Hyperphosphorylated tau disrupts microtubule integrity, impairing KIF21A-mediated transport |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KIF21A["KIF21A"]
neurodegeneration["neurodegeneration"]
KIF21A -->|"implicated_in"| neurodegeneration
style KIF21A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KIF21A in their description or question text
No additional research found