gene

KIF21B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF21B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

KIF21B is a neuronal kinesin motor protein involved in intracellular transport, neuronal migration, and dendritic spine morphology. Mutations are associated with neurodevelopmental disorders and Alzheimer's disease risk.

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🧬 Gene Info

Gene Symbol	KIF21B
Full Name	Kinesin Family Member 21B
Chromosome	1p31.3
Function	is a plus-end-directed motor protein belonging to the kinesin family that plays critical roles in neuronal development, intracellular transport, and synaptic function.
Primary Expression	the central nervous system, with particularly high levels in the cerebral cortex, hippocampus, and cerebellum, where it contributes to dendritic devel
Molecular Weight	190 kDa
Amino Acids	756 aa
Exons	38
UniProt ID	Q9Y4G1
NCBI Gene ID	22873
Ensembl ID	ENSG00000145794
GeneCards	KIF21B
Human Protein Atlas	KIF21B
Motor (Head) Domain	N-terminal (1-350 aa)
Coiled-coil Regions	Middle (350-1200 aa)
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KIF21B — AlphaFold Q9Y4G1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KIF21B["KIF21B"]
    neurodegeneration["neurodegeneration"]
    KIF21B -->|"implicated_in"| neurodegeneration
    style KIF21B fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found