Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIF9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KIF9 is a plus-end-directed kinesin motor protein involved in microtubule transport, ciliary function, and implicated in Parkinson's disease and ciliopathies
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| Gene Symbol | KIF9 |
| Full Name | Kinesin Family Member 9 |
| Chromosome | 3p21.31 |
| Function | is a member of the kinesin-9 family encoding a plus-end-directed motor protein that transports cargo along microtubules. |
| Primary Expression | multiple tissues: |
| Amino Acids | 655 aa |
| UniProt ID | Q9HAQ7 |
| NCBI Gene ID | 64143 |
| Ensembl ID | ENSG00000057189 |
| GeneCards | KIF9 |
| Human Protein Atlas | KIF9 |
| N-terminal motor domain (aa 1-350) | Contains the microtubule-binding motor core with ATP-binding and hydrolysis motifs. The motor domain mediates ATP-dependent movement along microtubules. |
| Coiled-coil regions (aa 350-550) | Mediate dimerization and cargo-binding interactions |
| C-terminal tail (aa 550-655) | Functions in cargo recognition and regulation |
| Organelle trafficking | Transport of vesicles, mitochondria, and protein complexes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KIF9["KIF9"]
neurodegeneration["neurodegeneration"]
KIF9 -->|"implicated_in"| neurodegeneration
style KIF9 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KIF9 in their description or question text
No additional research found