protein

KIR21PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIR21PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Kir2.1, encoded by the KCNJ2 gene, is a member of the inward rectifier potassium channel family (Kir2.x) that plays critical roles in maintaining neuronal resting membrane potential, controlling excitability, and regulating synaptic transmission.

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🔬 Protein Info

Gene Symbol	KIR21PROTEIN
Full Name	Kir2.1
Protein Type	Protein
Function	is a member of the inward rectifier potassium channel family (Kir2.
Primary Expression	cardiac tissue and skeletal muscle - PIP₂ Dependence: The essential role of PIP₂ creates complexity in modulating channel activity - Blood-Brain
UniProt ID	Search UniProt
GeneCards	KIR21PROTEIN
Human Protein Atlas	KIR21PROTEIN
Resting Membrane Potential	Kir2.1 is the major conductance determining the resting membrane potential in many neuron types, typically maintaining around -70 mV
Repolarization	These channels contribute to the final repolarization phase of action potentials
Excitability Control	By setting the resting potential, Kir2.1 directly influences neuronal excitability and firing properties
Potassium Buffering	Kir2.1 helps regulate extracellular potassium levels during neuronal activity
Synaptic Integration	The channels influence synaptic integration by modulating input resistance
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KIR21PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Kir2.1 Protein

protein · 1192 words

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Pathway Diagram

graph TD
    KIR21PROTEIN["KIR21PROTEIN"]
    neurodegeneration["neurodegeneration"]
    KIR21PROTEIN -->|"implicated_in"| neurodegeneration
    style KIR21PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning KIR21PROTEIN in their description or question text

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