Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIR23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KIR23 |
| Full Name | Kir2.3 (Inward Rectifier Potassium Channel 2.3) |
| Protein Family | Inward rectifier potassium channel (Kir2.x) |
| Protein Type | Channel |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | the plasma membrane, with enrichment in postsynaptic densities |
| Molecular Weight | ~48 kDa |
| UniProt ID | P48745 |
| GeneCards | KIR23 |
| Human Protein Atlas | KIR23 |
| Two transmembrane domains | M1 and M2 helices that span the lipid bilayer |
| P-loop region | Forms the selectivity filter with the characteristic GYG motif that confers K+ selectivity |
| N-terminus and C-terminus | Cytoplasmic domains that regulate channel activity through interactions with PIP2 and polyamines |
| Polyamine binding site | Located in the cytoplasmic pore, responsible for strong inward rectification |
| PIP2 binding site | Phosphatidylinositol 4,5-bisphosphate is required for channel activation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KIR23["KIR23"]
neurodegeneration["neurodegeneration"]
KIR23 -->|"implicated_in"| neurodegeneration
style KIR23 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KIR23 in their description or question text
No additional research found