gene

KMT2E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KMT2E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Comprehensive information on KMT2E (MLL5) gene encoding a histone H3K4 methyltransferase with critical roles in neurodevelopment, cognitive function, synaptic plasticity, and implicated in Alzheimer's disease, Parkinson's disease, and intellectual disability

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🧬 Gene Info

Gene Symbol	KMT2E
Chromosome	7q22.1
Protein Type	Transferase
Function	is a human gene located on chromosome 7q22.
Subcellular Localization	transcription factors, involved in transcriptional activation - SET domain:
Ensembl ID	ENSG00000155438
GeneCards	KMT2E
Human Protein Atlas	KMT2E
PHD finger (Plant Homeodomain)	A zinc finger domain that mediates protein-protein interactions and chromatin binding
FYR domain	Found in transcription factors, involved in transcriptional activation
SET domain	The catalytic domain responsible for histone methyltransferase activity
TPR repeats	Tetratricopeptide repeats mediating protein-protein interactions
N-terminal region	Contains sequences for nuclear localization and interaction with other chromatin regulators
H3K4me1	Enhancer-associated mark, important for regulatory element activation
H3K4me3	Promoter-associated mark, correlates with gene activation
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KMT2E Gene (Lysine Methyltransferase 2E)

gene · 3003 words

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Pathway Diagram

graph TD
    KMT2E["KMT2E"]
    neurodegeneration["neurodegeneration"]
    KMT2E -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    KMT2E -->|"implicated in"| Alzheimer_S_Disease
    Parkinson_S_Disease{"Parkinson'S Disease"}
    KMT2E -->|"implicated in"| Parkinson_S_Disease
    Synaptic_Plasticity(["Synaptic Plasticity"])
    KMT2E -->|"regulates"| Synaptic_Plasticity
    style KMT2E fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Synaptic_Plasticity fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KMT2E in their description or question text

No additional research found