Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KRIT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Gene Symbol | KRIT1 |
| Full Name | Krev Interaction Trapped 1 (CCM1) |
| Aliases | CCM1, KAI1, CDH5-associated protein |
| Chromosome | 7q21.2 |
| Protein Type | Scaffold Protein |
| Function | is a critical scaffold protein that regulates vascular development, endothelial cell junction stability, and intracellular signaling. |
| Primary Expression | Endothelium, Brain (cortex, hippocampus), Heart, Lung |
| Molecular Weight | ~82 kDa |
| Amino Acids | 736 aa |
| UniProt ID | [Q5JWB5](https://www.uniprot.org/uniprot/Q5JWB5) |
| NCBI Gene ID | 889 |
| Ensembl ID | ENSG00000033122 |
| OMIM | 604214 |
| GeneCards | KRIT1 |
| Human Protein Atlas | KRIT1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KRIT1["KRIT1"]
neurodegeneration["neurodegeneration"]
KRIT1 -->|"implicated_in"| neurodegeneration
style KRIT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||