protein

KV31PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KV31PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	KV31PROTEIN
Full Name	Kv3.1
Protein Type	Protein
Function	is a member of the Shaw-related family of voltage-gated potassium channels (Kv3 subfamily).
Primary Expression	fast-spiking GABAergic interneurons, including parvalbumin-positive basket cells and chandelier cells, where they are essential for precise temporal c
Subcellular Localization	s and functional properties
UniProt ID	Search UniProt
GeneCards	KV31PROTEIN
Human Protein Atlas	KV31PROTEIN
Fast Activation	Voltage-dependent activation occurs within 1-2 ms
Fast Deactivation	Rapid closure upon membrane repolarization
High Threshold	Channels activate at relatively depolarized potentials (around -10 to +10 mV)
Broadened Action Potentials	In neurons expressing Kv3.1, action potentials are shorter in duration
Reduced AHP	Decreased afterhyperpolarization enables rapid firing
Cerebral Cortex	Predominantly in parvalbumin (PV)-positive interneurons
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KV31PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Kv3.1 Protein

protein · 1273 words

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Pathway Diagram

graph TD
    KV31PROTEIN["KV31PROTEIN"]
    neurodegeneration["neurodegeneration"]
    KV31PROTEIN -->|"implicated_in"| neurodegeneration
    style KV31PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning KV31PROTEIN in their description or question text

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