protein

KV72

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KV72: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	KV72
Full Name	Kv7.2 (KCNQ2)
Protein Family	Voltage-gated potassium channels (Kv7/KCNQ)
Protein Type	Channel
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	~100 kDa
UniProt ID	O43526
GeneCards	KV72
Human Protein Atlas	KV72
M-current	Mediates slowly activating potassium current
Neuronal excitability	Determines firing threshold and pattern
Seizure suppression	Prevents hyperexcitability
Disease associations	Benign familial neonatal seizures, epileptic encephalopathy, migraine
S1-S4	Voltage-sensing domain (S4 carries positive charges)
S5-S6	Pore domain (selectivity filter: GYG)
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KV72 — AlphaFold O43526 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Kv7.2 (KCNQ2) Protein

protein · 848 words

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Pathway Diagram

graph TD
    KV72["KV72"]
    neurodegeneration["neurodegeneration"]
    KV72 -->|"implicated_in"| neurodegeneration
    style KV72 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning KV72 in their description or question text

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