Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LAS1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LAS1L |
| Full Name | LAS1 Like Ribosome Biogenesis Factor |
| Chromosome | Xq12 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 78 kDa |
| Amino Acids | 750 aa |
| UniProt ID | [Q9Y5W7](https://www.uniprot.org/uniprot/Q9Y5W7) |
| Ensembl ID | ENSG00000053592 |
| GeneCards | LAS1L |
| Human Protein Atlas | LAS1L |
| SLAIN2-binding domain | Interaction with SLAIN2 for proper localization |
| Late assembly domain | Critical for late stages of 60S maturation |
| Nucleolar targeting domain | Directs protein to nucleolar compartment |
| 60S Ribosomal Subunit Maturation | LAS1L participates in the late maturation steps of the 60S ribosomal subunit, including the release of the transit peptide and assembly of the ribosomal proteins |
| Nucleolar Localization | The protein localizes to the nucleolar fibrillar center and dense fibrillar component where pre-rRNA transcription and processing occur |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LAS1L["LAS1L"]
neurodegeneration["neurodegeneration"]
LAS1L -->|"implicated_in"| neurodegeneration
style LAS1L fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LAS1L in their description or question text
No additional research found