gene

LGI2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about LGI2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene profile: LGI2, secreted synaptic protein

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🧬 Gene Info

Gene Symbol	LGI2
Full Name	Leucine-Rich Glioma Inactivated 2
Chromosome	4p15.2
Function	is a secreted neuronal protein that belongs to the LGI family of leucine-rich repeat (LRR) domain-containing proteins.
Primary Expression	the brain, particularly in the hippocampus and cerebral cortex
Subcellular Localization	presynaptic terminals, where it may function in axonal guidance and presynaptic organization [Citation 6]
Amino Acids	509 aa
Exons	10
GeneCards	LGI2
Human Protein Atlas	LGI2
Leucine-rich repeats	14 LRR motifs forming a curved solenoid structure
EGF domains	Three EGF-like repeats, two of which bind calcium
Disulfide bonds	Multiple cysteine residues stabilizing domain interactions
N-linked glycosylation	Conserved glycosylation sites in the LRR domain
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LGI2 — Leucine-Rich Glioma Inactivated 2

gene · 1876 words

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Pathway Diagram

graph TD
    LGI2["LGI2"]
    neurodegeneration["neurodegeneration"]
    LGI2 -->|"implicated_in"| neurodegeneration
    style LGI2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning LGI2 in their description or question text

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